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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | G | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Jason Vargas | 120 | 2009 | |
| 2 | Brian Evins | 119 | 2019 | |
| 3 | Brian Evins | 118 | 2017 | |
| 4 | Paul Money | 116 | 2011 | |
| 5 | Francisco Liriano | 115 | 2012 | |
| 6 | William Pero | 113 | 2016 | |
| 6 | Karl Brumbelow | 113 | 2017 | |
| 8 | Brian Evins | 112 | 2018 | |
| 8 | Earl Aderholt | 112 | 2021 | |
| 10 | William Pero | 111 | 2015 | |
| 10 | Grant Roberts | 111 | 2008 | |
| 12 | Jason Vargas | 110 | 2008 | |
| 12 | Joe Valentine | 110 | 2008 | |
| 12 | Howard Barefield | 110 | 2017 | |
| 15 | Yuujin Seiichi | 109 | 2022 | |
| 15 | Karl Brumbelow | 109 | 2011 | |
| 15 | Grant Roberts | 109 | 2012 | |
| 18 | Robert Crumrine | 108 | 2022 | |
| 18 | Aldo Corrado | 108 | 2012 | |
| 18 | Derick Miller | 108 | 2016 | |
| 18 | Jose Guevara | 108 | 2016 | |
| 18 | Albert Pedro | 108 | 2020 | |
| 18 | Luis Ramirez | 108 | 2020 | |
| 18 | Michael Slone | 108 | 2016 | |
| 25 | Brett Tomko | 107 | 2007 | |
| 25 | Jason Anderson | 107 | 2008 | |
| 25 | Donald Burke | 107 | 2022 | |
| 28 | Michael Slone | 106 | 2017 | |
| 28 | Donald Frey | 106 | 2015 | |
| 28 | Robert Crumrine | 106 | 2019 | |
| 28 | Michael Slone | 106 | 2015 | |
| 28 | Robert Piotrowski | 106 | 2018 | |
| 28 | Derick Miller | 106 | 2017 | |
| 34 | Brian Bruney | 105 | 2005 | |
| 34 | Jason Vargas | 105 | 2010 | |
| 34 | Eric Knott | 105 | 2007 | |
| 34 | Brian Evins | 105 | 2016 | |
| 34 | Luis Ramirez | 105 | 2021 | |
| 34 | Kent Brinson | 105 | 2013 | |
| 34 | Shawn Chacon | 105 | 2006 | |
| 34 | Kevin Espana | 105 | 2019 | |
| 34 | Lino Urdaneta | 105 | 2016 | |
| 34 | Michael McCully | 105 | 2014 | |
| 34 | Leo Rosales | 105 | 2006 | |
| 34 | Henry Hayes | 105 | 2013 | |
| 34 | Chas Drum | 105 | 2017 | |
| 34 | Henry Jacobson | 105 | 2020 | |
| 48 | Shaun Marcum | 104 | 2014 | |
| 48 | Robert Cohen | 104 | 2022 | |
| 48 | Ryan Wagner | 104 | 2009 | |
| 48 | Donald Frey | 104 | 2013 | |
| 48 | Sal Brower | 104 | 2007 | |
| 48 | Carlos De La Cruz | 104 | 2009 | |
| 48 | Dwight Houghtaling | 104 | 2017 | |
| 48 | Ryan Wagner | 104 | 2013 | |
| 48 | Henry Jacobson | 104 | 2022 | |
| 48 | Kyle Waldrop | 104 | 2014 | |
| 48 | Felix Ibañez | 104 | 2022 | |
| 59 | Bill Bray | 103 | 2012 | |
| 59 | Ted Dawe | 103 | 2014 | |
| 59 | Trever Miller | 103 | 2005 | |
| 59 | Felix Ibañez | 103 | 2021 | |
| 59 | Eddy Rodriguez | 103 | 2016 | |
| 59 | Aldo Corrado | 103 | 2010 | |
| 59 | David Aardsma | 103 | 2014 | |
| 59 | Travis Driskill | 103 | 2005 | |
| 59 | Eduardo Sierra | 103 | 2008 | |
| 59 | Karl Brumbelow | 103 | 2012 | |
| 59 | Sam Marsonek | 103 | 2008 | |
| 59 | Octavio Dotel | 103 | 2005 | |
| 59 | Donald Burke | 103 | 2018 | |
| 72 | Aldo Corrado | 102 | 2013 | |
| 72 | Jason Ryan | 102 | 2006 | |
| 72 | Salvador Otero | 102 | 2022 | |
| 72 | Jose Valverde | 102 | 2006 | |
| 72 | Ray King | 102 | 2007 | |
| 77 | Scott Strickland | 101 | 2005 | |
| 77 | Raúl De Jesús# | 101 | 2063 | |
| 77 | Norbert Ware | 101 | 2021 | |
| 77 | Oscar Villarreal | 101 | 2013 | |
| 77 | Ray King | 101 | 2008 | |
| 77 | Lawrence Hodge | 101 | 2014 | |
| 77 | Chad Wells | 101 | 2019 | |
| 84 | Aneudis Mateo | 100 | 2008 | |
| 84 | Robert Crumrine | 100 | 2018 | |
| 84 | Jose Santiago | 100 | 2009 | |
| 84 | Matt Mantei | 100 | 2006 | |
| 84 | Brendan Donnelly | 100 | 2005 | |
| 84 | Chas Drum | 100 | 2020 | |
| 84 | Kent Brinson | 100 | 2017 | |
| 84 | Brian Evins | 100 | 2020 | |
| 84 | Greg Jones | 100 | 2008 | |
| 84 | Hector Bolaños | 100 | 2011 | |
| 84 | Les Thomas | 100 | 2020 | |
| 84 | Pasqual Gonzalez | 100 | 2021 | |
| 84 | Dominic Raffaele | 100 | 2021 | |
| 84 | Greg Jones | 100 | 2006 | |
| 84 | Troy Percival | 100 | 2007 | |
| 84 | John Riedling | 100 | 2005 | |
| 84 | Donald Burke | 100 | 2020 |
