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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Gaby Garza* | 5357 | 2011-2034 | |
| 2 | Arthur Breckenridge* | 4985 | 2016-2038 | |
| 3 | Alfredo Perez* | 4855 | 2012-2037 | |
| 4 | Teodoro Erazo* | 4852 | 2017-2040 | |
| 5 | José Álvarez# | 4699 | 2046-2066 | |
| 6 | Salvador Ibarra* | 4664 | 2040-2058 | |
| 7 | Juan Rodríguez | 4617 | 2044-2063 | |
| 8 | Roger Clemens* | 4397 | 1984-2005 | |
| 9 | Mark Prior* | 4315 | 2002-2019 | |
| 10 | Greg Miller* | 4295 | 2006-2023 | |
| 11 | Randy Johnson* | 4292 | 1989-2006 | |
| 12 | Corey McDonald* | 4225 | 2031-2052 | |
| 13 | Edwin Jackson* | 4221 | 2003-2022 | |
| 14 | Jesse Bashaw# | 4175 | 2050-2066 | |
| 15 | Neill Oulton* | 4119 | 2038-2054 | |
| 16 | Earl French* | 4105 | 2031-2048 | |
| 17 | Alfred Fellers* | 4097 | 2009-2027 | |
| 18 | César Salinas# | 4042 | 2046-2066 | |
| 19 | Doug Bennett | 4032 | 2042-2061 | |
| 20 | Steve Carlton* | 4016 | 1965-1988 | |
| 21 | Ching Lung Lo | 4003 | 2006-2028 | |
| 22 | Robert Sayler | 3999 | 2016-2037 | |
| 23 | Stanley Desimone# | 3997 | 2052-2066 | |
| 24 | Leon Rodriguez* | 3993 | 2019-2037 | |
| 25 | Roberto Rivera | 3897 | 2030-2050 | |
| 26 | Jerry Smith | 3884 | 2017-2034 | |
| 27 | Scott Fitzpatrick | 3857 | 2038-2060 | |
| 28 | Steve Hillery | 3839 | 2016-2034 | |
| 29 | Charles West | 3837 | 2039-2056 | |
| 30 | José Manuel | 3666 | 2036-2051 | |
| 31 | Tony Venegas | 3642 | 2011-2024 | |
| 32 | Greg Hill* | 3615 | 2037-2056 | |
| 33 | John Zinn | 3594 | 2019-2034 | |
| 34 | Shinsui Kichida | 3562 | 2032-2049 | |
| 35 | Leland Patterson | 3560 | 2030-2050 | |
| 36 | Freddy Román | 3546 | 2028-2041 | |
| 37 | Joel Pineiro | 3515 | 2000-2018 | |
| 38 | Emory Osborn | 3497 | 2026-2044 | |
| 39 | Manuel González* | 3447 | 2039-2053 | |
| 40 | Bert Blyleven | 3431 | 1970-1988 | |
| 41 | Tony Palácios | 3406 | 2041-2057 | |
| 42 | Desmond Greenwood | 3403 | 2045-2061 | |
| 43 | Nick Kelly* | 3399 | 2034-2054 | |
| 44 | Bob Flory | 3396 | 2016-2036 | |
| 45 | Curtis Pineda | 3376 | 2015-2030 | |
| 46 | Gerald Donaldson* | 3364 | 2010-2029 | |
| 47 | Tyler Clippard | 3342 | 2006-2022 | |
| 48 | Ramón Gómez | 3324 | 2036-2052 | |
| 49 | Dave Brown | 3309 | 2045-2059 | |
| 50 | Higinio Bueno | 3297 | 2022-2039 | |
| 51 | Rubén González | 3282 | 2033-2051 | |
| 52 | C.C. Sabathia | 3257 | 2001-2018 | |
| 53 | Roland Noyola* | 3250 | 2009-2027 | |
| 53 | Salvador Rangel | 3250 | 2027-2048 | |
| 55 | Román Pérez | 3246 | 2029-2045 | |
| 56 | Travis Alexander | 3235 | 2036-2053 | |
| 57 | Jame Raskin | 3233 | 2017-2033 | |
| 58 | Tony Paylor* | 3222 | 2035-2049 | |
| 59 | Viriato Malh* | 3218 | 2036-2055 | |
| 60 | Joe Mason | 3190 | 2032-2046 | |
| 61 | Willie Calhoun | 3185 | 2022-2039 | |
| 62 | Hai Fons | 3174 | 2010-2029 | |
| 63 | César Mendoza* | 3141 | 2032-2048 | |
| 64 | Bob Gibson | 3117 | 1959-1975 | |
| 65 | Jose Fajardo | 3115 | 2017-2030 | |
| 66 | Lawrence Hodge | 3112 | 2007-2020 | |
| 67 | Rodney Jones# | 3110 | 2051-2066 | |
| 68 | Thomas Diamond* | 3101 | 2008-2021 | |
| 69 | Dustin McGowan | 3096 | 2004-2020 | |
| 70 | Jeffrey Bancroft | 3073 | 2041-2058 | |
| 71 | Rubén Rodríguez# | 3070 | 2046-2065 | |
| 72 | Norberto López* | 3060 | 2041-2058 | |
| 73 | Phil Niekro* | 3000 | 1966-1987 | |
| 74 | Dan Miller | 2993 | 2033-2049 | |
| 75 | Roy Halladay | 2981 | 1998-2016 | |
| 76 | Curt Schilling | 2930 | 1988-2006 | |
| 77 | James Lanz | 2929 | 2020-2036 | |
| 78 | José Rivera# | 2926 | 2052-2066 | |
| 79 | Pedro Martinez* | 2923 | 1992-2009 | |
| 79 | Joseph McLaughlin* | 2923 | 2016-2030 | |
| 81 | Devin Burchell | 2922 | 2016-2036 | |
| 82 | Keith Fenimore | 2915 | 2022-2037 | |
| 83 | Kris Honel | 2900 | 2006-2021 | |
| 84 | Júlio Palma# | 2893 | 2050-2066 | |
| 85 | Teinosuke Maekawa* | 2891 | 2031-2048 | |
| 85 | Ken Smith | 2891 | 2031-2045 | |
| 87 | Marty Scott | 2875 | 2030-2043 | |
| 88 | Antonio Reno* | 2874 | 2009-2024 | |
| 89 | Brandon Webb | 2869 | 2003-2020 | |
| 90 | Adriano Rosario | 2857 | 2005-2023 | |
| 91 | Greg Maddux* | 2854 | 1986-2004 | |
| 92 | Paul Carvalho | 2853 | 2023-2040 | |
| 93 | Sergio Chavarriaga | 2842 | 2027-2042 | |
| 94 | Mike Mussina | 2841 | 1991-2007 | |
| 95 | Adam Oyola | 2838 | 2023-2036 | |
| 96 | Irving Peterson | 2827 | 2034-2052 | |
| 97 | Josh Beckett | 2823 | 2001-2017 | |
| 98 | Barry Zito | 2819 | 2000-2018 | |
| 99 | Carlos Olivos | 2816 | 2031-2047 | |
| 100 | Xavier López | 2810 | 2042-2058 |
