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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | SHO | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Pete Alexander* | 64 | 1911-1930 | |
| 2 | Bob Gibson | 56 | 1959-1975 | |
| 3 | Bert Blyleven | 55 | 1970-1988 | |
| 3 | Steve Carlton* | 55 | 1965-1988 | |
| 5 | Jim Palmer* | 53 | 1965-1984 | |
| 6 | Cy Young* | 50 | 1899-1910 | |
| 7 | Roger Clemens* | 47 | 1984-2005 | |
| 8 | Greg Miller* | 45 | 2006-2023 | |
| 9 | Bob Feller* | 44 | 1936-1956 | |
| 9 | Robin Roberts | 44 | 1948-1965 | |
| 11 | Phil Niekro* | 43 | 1966-1987 | |
| 12 | Jim Bunning* | 40 | 1955-1971 | |
| 13 | Mickey Lolich | 39 | 1963-1975 | |
| 14 | Roland Noyola* | 38 | 2009-2027 | |
| 15 | Eppa Rixey* | 37 | 1912-1933 | |
| 16 | Randy Johnson* | 35 | 1989-2006 | |
| 17 | Greg Maddux* | 34 | 1986-2004 | |
| 18 | Hal Newhouser* | 33 | 1939-1955 | |
| 19 | Scott Fitzpatrick | 32 | 2038-2060 | |
| 20 | Stan Coveleski* | 31 | 1916-1924 | |
| 20 | Catfish Hunter* | 31 | 1965-1974 | |
| 20 | Bob Lemon* | 31 | 1946-1958 | |
| 23 | Neill Oulton* | 29 | 2038-2054 | |
| 24 | Gaylord Perry* | 27 | 1972-1982 | |
| 24 | Mark Prior* | 27 | 2002-2019 | |
| 26 | Alfredo Perez* | 26 | 2012-2037 | |
| 27 | Mike Mussina | 25 | 1991-2007 | |
| 28 | Alfred Fellers* | 24 | 2009-2027 | |
| 28 | Jesse Haines* | 24 | 1918-1937 | |
| 28 | Vic Willis* | 24 | 1906-1910 | |
| 28 | Early Wynn* | 24 | 1949-1963 | |
| 32 | Dizzy Dean* | 23 | 1930-1937 | |
| 32 | Roy Halladay | 23 | 1998-2016 | |
| 34 | William Benefiel* | 22 | 2023-2036 | |
| 34 | David Cone | 22 | 1986-2004 | |
| 34 | Tom Glavine* | 22 | 1987-2004 | |
| 34 | Curtis Pineda | 22 | 2015-2030 | |
| 38 | Salvador Ibarra* | 21 | 2040-2058 | |
| 39 | Thomas Diamond* | 20 | 2008-2021 | |
| 39 | Fergie Jenkins* | 20 | 1965-1981 | |
| 39 | Curt Schilling | 20 | 1988-2006 | |
| 42 | Ronald Garnica | 19 | 2014-2026 | |
| 42 | Nolan Ryan* | 19 | 1980-1991 | |
| 44 | Doug Bennett | 18 | 2042-2061 | |
| 44 | Dennis Eckersley* | 18 | 1975-1998 | |
| 44 | Gerardo García* | 18 | 2033-2051 | |
| 44 | Edwin Jackson* | 18 | 2003-2022 | |
| 48 | Kevin Brown | 17 | 1986-2005 | |
| 48 | Jack Chesbro* | 17 | 1899-1909 | |
| 48 | Scott Erickson | 17 | 1990-2004 | |
| 48 | Manuel González* | 17 | 2039-2053 | |
| 48 | Babe Ruth* | 17 | 1914-1919 | |
| 53 | Jesse Bashaw# | 16 | 2050-2066 | |
| 53 | Pud Galvin* | 16 | 1886-1892 | |
| 53 | Rubén González | 16 | 2033-2051 | |
| 53 | Charles West | 16 | 2039-2056 | |
| 57 | Earl French* | 15 | 2031-2048 | |
| 57 | Lefty Grove* | 15 | 1934-1941 | |
| 57 | James Rogers | 15 | 2048-2060 | |
| 57 | Tom Seaver* | 15 | 1977-1986 | |
| 57 | Javier Vazquez | 15 | 2004-2016 | |
| 62 | Higinio Bueno | 14 | 2022-2039 | |
| 62 | Ching Lung Lo | 14 | 2006-2028 | |
| 62 | Corey McDonald* | 14 | 2031-2052 | |
| 62 | John Smoltz | 14 | 1988-2006 | |
| 62 | David Wells | 14 | 1987-2004 | |
| 62 | Barry Zito | 14 | 2000-2018 | |
| 68 | Jerry Agee | 13 | 2013-2030 | |
| 68 | Alfredo Barraza | 13 | 2025-2040 | |
| 68 | Paul Byrd | 13 | 1995-2007 | |
| 68 | Doug Farrell | 13 | 2044-2059 | |
| 68 | Kevin Millwood | 13 | 1997-2010 | |
| 68 | Herb Pennock* | 13 | 1915-1934 | |
| 68 | César Salinas# | 13 | 2046-2066 | |
| 75 | Kevin Appier | 12 | 1989-2004 | |
| 75 | Chris Ashling# | 12 | 2056-2066 | |
| 75 | Jeffrey Bancroft | 12 | 2041-2058 | |
| 75 | Dave Brown | 12 | 2045-2059 | |
| 75 | Gaby Garza* | 12 | 2011-2034 | |
| 75 | Jake Gilmer | 12 | 2018-2032 | |
| 75 | William Hill | 12 | 2029-2048 | |
| 75 | Brett Myers | 12 | 2002-2017 | |
| 75 | Leland Patterson | 12 | 2030-2050 | |
| 75 | Joel Pineiro | 12 | 2000-2018 | |
| 75 | Juan Rodríguez | 12 | 2044-2063 | |
| 75 | Rubén Rodríguez# | 12 | 2046-2065 | |
| 75 | Randy Wolf | 12 | 1999-2011 | |
| 88 | Pedro Astacio | 11 | 1992-2003 | |
| 88 | Mike Beasley# | 11 | 2050-2066 | |
| 88 | Josh Beckett | 11 | 2001-2017 | |
| 88 | Paul Carvalho | 11 | 2023-2040 | |
| 88 | Tyler Clippard | 11 | 2006-2022 | |
| 88 | Ramón Gómez | 11 | 2036-2052 | |
| 88 | Mary Hiltner | 11 | 2018-2034 | |
| 88 | Walter Holub | 11 | 2021-2038 | |
| 88 | Bob Kenney | 11 | 2033-2050 | |
| 88 | Al Leiter | 11 | 1987-2005 | |
| 88 | José Manuel | 11 | 2036-2051 | |
| 88 | Pedro Martinez* | 11 | 1992-2009 | |
| 88 | Mark Mulder | 11 | 2000-2013 |
