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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | L | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Amando Demony* | 273 | 2031-2053 | |
| 2 | Phil Niekro* | 251 | 1966-1987 | |
| 2 | Eppa Rixey* | 251 | 1912-1933 | |
| 4 | Luke Bone | 250 | 2013-2033 | |
| 5 | Teodoro Erazo* | 249 | 2017-2040 | |
| 6 | Dan Miller | 244 | 2033-2049 | |
| 7 | Freddy Rodríguez | 240 | 2035-2053 | |
| 8 | Robin Roberts | 237 | 1948-1965 | |
| 9 | Arthur Breckenridge* | 234 | 2016-2038 | |
| 10 | Steve Carlton* | 230 | 1965-1988 | |
| 11 | William Hill | 229 | 2029-2048 | |
| 12 | Gaby Garza* | 228 | 2011-2034 | |
| 13 | Bert Blyleven | 226 | 1970-1988 | |
| 14 | Chad Birch | 225 | 2028-2045 | |
| 14 | Roberto Rivera | 225 | 2030-2050 | |
| 16 | Rubén González | 223 | 2033-2051 | |
| 16 | Robert Sayler | 223 | 2016-2037 | |
| 18 | Salvador Rangel | 219 | 2027-2048 | |
| 18 | Carl Richardson | 219 | 2034-2055 | |
| 20 | Dave Carrizal | 218 | 2038-2055 | |
| 20 | Reese Larsen | 218 | 2042-2057 | |
| 22 | Scott Fitzpatrick | 217 | 2038-2060 | |
| 22 | Hai Fons | 217 | 2010-2029 | |
| 24 | Rich Smith | 216 | 2036-2052 | |
| 25 | César Salinas# | 215 | 2046-2066 | |
| 26 | Charles West | 213 | 2039-2056 | |
| 27 | Travis Alexander | 208 | 2036-2053 | |
| 27 | Alfredo Barraza | 208 | 2025-2040 | |
| 27 | Román Pérez | 208 | 2029-2045 | |
| 30 | Royce Roberts | 207 | 2034-2051 | |
| 31 | Ramón Gómez | 206 | 2036-2052 | |
| 32 | Albert Castro# | 205 | 2052-2065 | |
| 33 | Earl French* | 204 | 2031-2048 | |
| 33 | Irving Peterson | 204 | 2034-2052 | |
| 35 | Doug Bennett | 203 | 2042-2061 | |
| 36 | Higinio Bueno | 201 | 2022-2039 | |
| 36 | Jeffrey Follansbee | 201 | 2023-2038 | |
| 36 | Leland Patterson | 201 | 2030-2050 | |
| 39 | Gerardo García* | 200 | 2033-2051 | |
| 39 | Gabriel Serrano | 200 | 2042-2058 | |
| 39 | Jerry Smith | 200 | 2017-2034 | |
| 42 | Victor Powell | 197 | 2041-2058 | |
| 43 | Dan White | 195 | 2029-2045 | |
| 44 | Joe Mason | 194 | 2032-2046 | |
| 45 | Xavier López | 193 | 2042-2058 | |
| 46 | Devin Burchell | 190 | 2016-2036 | |
| 46 | Paul Carvalho | 190 | 2023-2040 | |
| 46 | Miguel Duran | 190 | 2017-2034 | |
| 46 | Rodney Jones# | 190 | 2051-2066 | |
| 46 | James Lanz | 190 | 2020-2036 | |
| 51 | Carlos Olivos | 189 | 2031-2047 | |
| 51 | Rubén Rodríguez# | 189 | 2046-2065 | |
| 53 | Gabriel Griffith | 188 | 2039-2053 | |
| 53 | Ching Lung Lo | 188 | 2006-2028 | |
| 55 | Marty Scott | 187 | 2030-2043 | |
| 56 | Jerry Agee | 186 | 2013-2030 | |
| 56 | Shinsui Kichida | 186 | 2032-2049 | |
| 56 | Freddie Kimsey | 186 | 2025-2036 | |
| 59 | Ed Fisher | 185 | 2045-2057 | |
| 60 | José Hernández | 184 | 2033-2045 | |
| 61 | Jeffrey Bancroft | 183 | 2041-2058 | |
| 61 | Cam Briggs* | 183 | 2031-2050 | |
| 61 | Harry Haggard | 183 | 2016-2030 | |
| 61 | Tony Palácios | 183 | 2041-2057 | |
| 61 | Jame Raskin | 183 | 2017-2033 | |
| 66 | Elvis Sanders# | 182 | 2051-2066 | |
| 67 | Steve Hillery | 181 | 2016-2034 | |
| 68 | Roger Clemens* | 180 | 1984-2005 | |
| 68 | Alfredo Perez* | 180 | 2012-2037 | |
| 68 | Douglas Stoffel | 180 | 2019-2036 | |
| 71 | Greg Hill* | 179 | 2037-2056 | |
| 71 | Robert Quayle | 179 | 2013-2029 | |
| 73 | Corey McDonald* | 177 | 2031-2052 | |
| 73 | Ramón Valenzuela | 177 | 2032-2046 | |
| 75 | Bob Flory | 176 | 2016-2036 | |
| 75 | Nick Kelly* | 176 | 2034-2054 | |
| 77 | Mickey Lolich | 175 | 1963-1975 | |
| 78 | Jim Bunning* | 174 | 1955-1971 | |
| 78 | Bob Gibson | 174 | 1959-1975 | |
| 78 | Art Giles | 174 | 2018-2030 | |
| 78 | Donald Hemming | 174 | 2036-2049 | |
| 78 | James Johnson | 174 | 2007-2021 | |
| 78 | Emory Osborn | 174 | 2026-2044 | |
| 78 | Thomas Souliere | 174 | 2019-2034 | |
| 85 | Steve Flowers | 173 | 2034-2050 | |
| 85 | Joseph Fulkerson | 173 | 2015-2031 | |
| 85 | Vicente Matos | 173 | 2034-2045 | |
| 85 | César Mendoza* | 173 | 2032-2048 | |
| 85 | Leon Rodriguez* | 173 | 2019-2037 | |
| 85 | Fred Swain | 173 | 2025-2044 | |
| 91 | Sergio Chavarriaga | 172 | 2027-2042 | |
| 91 | Matt Clement | 172 | 1998-2011 | |
| 91 | Jose Fajardo | 172 | 2017-2030 | |
| 91 | Bill Miller | 172 | 2043-2055 | |
| 91 | Cy Young* | 172 | 1899-1910 | |
| 96 | Lonnie Bowling | 171 | 2015-2034 | |
| 96 | Willie Calhoun | 171 | 2022-2039 | |
| 98 | Garry Calabrese | 170 | 2019-2034 | |
| 98 | Tom Glavine* | 170 | 1987-2004 | |
| 100 | Duane Cadwallader | 169 | 2041-2054 |
