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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Ramon Vilardebo* | 789 | 2012-2035 | |
| 2 | Roger Tarozaemon* | 769 | 2019-2042 | |
| 3 | Juan Lamas* | 722 | 2007-2028 | |
| 4 | Emmett Taylor | 715 | 2045-2064 | |
| 5 | Barry Bonds* | 712 | 1986-2004 | |
| 6 | Alex Rodriguez* | 707 | 1994-2013 | |
| 7 | Ángel Martínez# | 699 | 2048-2066 | |
| 8 | Bob Fields* | 679 | 2035-2056 | |
| 9 | Robert Alejandro* | 671 | 2008-2026 | |
| 10 | Jon Byram* | 651 | 2029-2045 | |
| 11 | Edward Laverriere* | 637 | 2013-2030 | |
| 12 | Tom Sackett* | 633 | 2034-2053 | |
| 13 | Stanton Downer* | 628 | 2017-2040 | |
| 14 | Manny Ramirez* | 625 | 1993-2012 | |
| 15 | Darrel Davis* | 614 | 2027-2049 | |
| 16 | Ken Griffey* | 610 | 1989-2008 | |
| 17 | William Wolfgram* | 606 | 2020-2038 | |
| 18 | Robert Yedinak* | 595 | 2024-2044 | |
| 19 | Clifford Nowlin* | 592 | 2010-2029 | |
| 20 | Joe Allen* | 591 | 2035-2053 | |
| 20 | Fredrick Lavedre | 591 | 2047-2066 | |
| 20 | Vernon Moore | 591 | 2048-2061 | |
| 23 | Martín González* | 589 | 2030-2047 | |
| 24 | Sammy Sosa* | 584 | 1989-2007 | |
| 25 | Mark McGwire* | 583 | 1986-2001 | |
| 25 | Jason Mills* | 583 | 2034-2055 | |
| 27 | Bill Frye# | 576 | 2049-2066 | |
| 27 | Wilson Murphy | 576 | 2044-2064 | |
| 29 | Hank Blalock* | 575 | 2002-2021 | |
| 30 | Frank Johnston# | 574 | 2052-2066 | |
| 31 | William Stadler* | 571 | 2022-2044 | |
| 32 | José Encarnación# | 570 | 2049-2066 | |
| 33 | Rafael Palmeiro* | 566 | 1986-2004 | |
| 34 | Joseph Lang* | 562 | 2007-2020 | |
| 35 | Peter Arceniaga* | 560 | 2021-2039 | |
| 36 | Eddie Talley | 553 | 2046-2063 | |
| 37 | José Diéguez# | 549 | 2049-2066 | |
| 38 | Steve Bolton | 548 | 2008-2024 | |
| 38 | Mike Schmidt* | 548 | 1972-1989 | |
| 40 | Bill Logan* | 543 | 2033-2054 | |
| 41 | Dwight Bachand | 542 | 2014-2030 | |
| 41 | Vaughn Helton | 542 | 2046-2061 | |
| 43 | Quincy Thornton | 540 | 2037-2054 | |
| 44 | Willard Noone* | 539 | 2005-2022 | |
| 45 | Larry Tomlinson | 538 | 2042-2063 | |
| 46 | Gary Musso* | 534 | 2024-2045 | |
| 47 | Frank Lesage* | 532 | 2016-2037 | |
| 48 | Lance Thomas* | 528 | 2043-2062 | |
| 49 | Bill Casselman* | 522 | 2017-2035 | |
| 50 | Ted Williams* | 521 | 1939-1960 | |
| 51 | Francisco Chávez* | 519 | 2040-2057 | |
| 51 | Juan Gonzalez* | 519 | 1989-2007 | |
| 53 | Juan Ruíz | 518 | 2043-2062 | |
| 54 | Nate Conley | 517 | 2043-2061 | |
| 54 | Sancho Rojas* | 517 | 2034-2055 | |
| 56 | Frank Robinson* | 515 | 1956-1976 | |
| 57 | José Mata | 514 | 2041-2059 | |
| 58 | Mark Garland# | 512 | 2055-2066 | |
| 59 | Germán Ramos# | 511 | 2051-2066 | |
| 59 | Brad Thompson | 511 | 2034-2048 | |
| 61 | Eldon Gordon* | 508 | 2032-2053 | |
| 62 | Tracy Rojas* | 507 | 2007-2020 | |
| 63 | Miguel Padua* | 498 | 2014-2030 | |
| 64 | Andrew Nelson# | 496 | 2053-2066 | |
| 65 | Rafael Rivera | 494 | 2030-2045 | |
| 65 | Jim Thome | 494 | 1991-2006 | |
| 67 | Ceasario Gargiulo* | 490 | 2030-2048 | |
| 67 | Francisco Reyes# | 490 | 2055-2066 | |
| 69 | Matthew Moses | 489 | 2010-2023 | |
| 70 | Todd Helton* | 487 | 1997-2012 | |
| 71 | José Peña* | 484 | 2031-2050 | |
| 71 | Michiichirou Washi* | 484 | 2026-2042 | |
| 73 | Joe Arrington | 479 | 2029-2045 | |
| 74 | Austin Kearns | 476 | 2002-2018 | |
| 74 | Roberto Medina | 476 | 2049-2063 | |
| 76 | Harmon Killebrew* | 475 | 1961-1974 | |
| 76 | Stan Musial* | 475 | 1941-1963 | |
| 76 | Willie Stargell* | 475 | 1962-1982 | |
| 79 | Buddy de Rijk# | 474 | 2055-2066 | |
| 80 | Bob Arthur* | 473 | 2036-2052 | |
| 80 | Pedro Casillas | 473 | 2047-2063 | |
| 80 | Gary Sheffield | 473 | 1992-2007 | |
| 80 | Allen Walker | 473 | 2045-2059 | |
| 84 | Ben Broussard | 472 | 2002-2017 | |
| 85 | Manny Gonzáles | 471 | 2028-2045 | |
| 85 | Dan Williams# | 471 | 2054-2066 | |
| 87 | Andruw Jones | 470 | 1996-2012 | |
| 87 | António Núñes | 470 | 2045-2062 | |
| 89 | Daniel Oliveros | 469 | 2016-2031 | |
| 90 | Connor Hooper | 467 | 2041-2058 | |
| 91 | Zander Perkins | 466 | 2047-2059 | |
| 91 | Enrique Segura* | 466 | 2036-2054 | |
| 93 | Frank Thomas | 465 | 1990-2005 | |
| 94 | Cristóbal López# | 462 | 2053-2066 | |
| 95 | Rod Charles# | 461 | 2055-2066 | |
| 96 | Jeff Bagwell | 460 | 1991-2006 | |
| 96 | Álex Romero | 460 | 2048-2061 | |
| 98 | William Brady | 458 | 2029-2045 | |
| 99 | Joaquín Mendoza | 454 | 2026-2040 | |
| 99 | Vernon Wells | 454 | 1999-2017 |
